Disorders of distal acidification
نویسندگان
چکیده
منابع مشابه
A mathematical model of distal nephron acidification: diuretic effects.
Through their action on the distal nephron (DN), diuretics may produce systemic acid-base disturbances: metabolic alkalosis with thiazides or loop diuretics and metabolic acidosis with amiloride. Enhanced acid excretion may be due to a local effect on the diuretic target cell (a shift of Na+ reabsorption from NaCl transport to Na+/H+ exchange), or an effect at a distance: namely, increases in l...
متن کاملThe mechanism of amphotericin-induced distal acidification defect in rats.
1. The effect of chronic and acute administration of amphotericin B on renal function, especially urinary acidification, was studied in rats. Chronic intraperitoneal administration of amphotericin B resulted in blood concentrations similar to or higher than those seen in patients treated with the antibiotic, but failed to produce hyperchloraemic acidosis. The minimum urine pH achieved during NH...
متن کاملSignification of distal urinary acidification defects in hypocitraturic patients
BACKGROUND AND OBJECTIVES Hypocitraturia has been associated with metabolic acidosis and mineral disorders. The aim of this study was to investigate the occurrence of urinary acidification defects underlying hypocitraturia. MATERIALS AND METHODS This retrospective observational study included 67 patients (32 men), aged 40.7±15.1 years with hypocitraturia (<1.67 mmol/24-h) and nephrolithiasis,...
متن کاملDepressed distal tubule acidification corrects chloride-deplete alkalosis in rats.
We investigated the relative contributions made by the proximal and distal tubule to the correction of Cl-deplete metabolic alkalosis induced by systemic administration of NaCl. Free-flow micropuncture was used to examine net bicarbonate reabsorption in superficial proximal and distal tubules of anesthetized Munich-Wistar rats during maintenance and correction of chronic furosemide-induced Cl-d...
متن کاملEndothelin-1 increases rat distal tubule acidification in vivo.
Because endothelin receptor inhibition blunts increased distal tubule acidification induced by dietary acid, we examined whether endothelin-1 (ET-1) increases acidification of in vivo perfused distal tubules of anesthetized rats. ET-1 was infused intra-aortically (1.4 pmol ⋅ kg-1 ⋅ min-1) into control animals and into those with increased distal tubule HCO3 secretion induced by drinking 80 mM N...
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ژورنال
عنوان ژورنال: Kidney International
سال: 1990
ISSN: 0085-2538
DOI: 10.1038/ki.1990.264